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维生素C参与产生一种全新的DNA修饰
发布时间:2019-05-23   点击次数:191次

5YUE2RI,GUOJIXUESHUQIKAN《ZIRAN》ZAIXIANFABIAOLELAIZIZHONGKEYUANSHANGHAISHENGWUHUAXUEYUXIBAOSHENGWUXUEYANJIUSUOXUGUOLIANGYUANSHILIANHEFUDANDAXUETANGHUIRUJIAOSHOUHEZHONGKEYUANWUHANSHUISHENGSHENGWUYANJIUSUOHUANGKAIYAOYANJIUYUANDENGDUOGEKETIZUHEZUOWANCHENGDEYANJIUCHENGGUO“Avitamin-C-derivedDNAmodificationcatalysedbyanalgalTEThomologue”。GAIYANJIUZAILAIYINYIZAO(Chlamydomonasreinhardtii)ZHEIZHONGDANXIBAOZHENHESHENGWUZHONGJIANDINGDAOYIZHONGXINXINGDETETTONGYUANDANBAI,BINGFAXIANGAIDANBAIKEYIJIANGWEISHENGSUCDETANJIGUJIAZHUANYIDAODNASHANG,CHANSHENGYIZHONGQUANXINDEDNAXIUSHI。WENZHANGXIANGXICHANSHULEWEISHENGSUCZHIJIECANYUGAIDNAXIUSHIDEFANYINGJILI,BINGJIESHIZHEIYIDANBAIJIQICHANSHENGDEDNAXIUSHIZAIDIAOJIELAIYINYIZAOGUANGHEZUOYONGGUOCHENGZHONGDEZHONGYAOZUOYONG。

 

 

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??ZAIxinFABIAODEGONGZUOZHONG,YANJIUZHEYILAIYINYIZAOZUOWEIMOSHISHENGWU,JIANDINGDAOLE8GETETTONGYUANDANBAI。TONGGUODANBAICHUNHUAYIJIMEIHUOFENXI,TAMENFAXIANQIZHONGDECrTET1KEYIJIANGDNASHANGDE5mCZHUANBIANWEILIANGZHONGBUTONGDEXIUSHIJIANJI,CrTET1YEYINCIBEIZHONGXINMINGMINGWEICMD1(5-methylcytosinemodificationenzyme1)。JINYIBUDEYANJIUBIAOMING,ZHEILIANGZHONGXINXIUSHIDOUSHIZAI5mCDEJIAJITANSHANGZENGJIALEYIGEGANYOUJI,ERZHEYOUYUKONGJIANJIEGOUDECHAYIERHUWEILITIYIGOUTI,YINCIJIANGQITONGYIMINGMINGWEI5-GANYOUJI-JIAJIBAOMIDING(5gmC)。ZHEIYESHICHULEMUQIANYIZHIDE5mC、5hmC、5fC、5caC、6mA、5hmUHEbaseJYIWAI,ZAIZHENHESHENGWUZHONGFAXIANDEDI8ZHONGDNAJIANJIXIUSHI。GENGJIAYIWAIDESHI,ZAIYANJIU5gmCSHANGGANYOUJIDELAIYUANSHI,YANJIUZHEFAXIANZAICHUANTONGSHUANGJIAYANGMEIFANYINGZHONGSUOBIXUDEα-TONGWUERSUANZAICMD1MEICUIHUAFANYINGZHONGKEYOUKEWU,QUERDAIZHIDESHILINGYIGESHIFENZHONGYAODEXIAOFENZI:WEISHENGSUC。WEISHENGSUCBUJINTONGGUOTIGONGDIANZICANYUCMD1DECUIHUAGUOCHENG,HAIZHIJIEJIANGZISHENDEGANYOUJITUANZHUANYIDAO5mCDEJIAJITANSHANG,XINGCHENGXINDEDNAXIUSHI。YANJIUZHEJINYIBUJIEXILECMD1CUIHUA5mCYUWEISHENGSUCFANYINGDEHUAXUEJILI,ZHENGSHIYIQUANSUANYUERYANGHUATANWEIFANYINGDEFUCHANWU,CONGERJIESHILEYITIAOQUANXINDEMEICUIHUATUJING。TONGGUOZAILAIYINYIZAOZHONGKAIFADEJIYINBIANJIFANGFA,YANJIUZHEHUODELECMD1JIYINTUBIANZAOZHU。CMD1TUBIANZAOZHUZAIQIANGGUANGZHAOSHEXIADESHIYINGNENGLIMINGXIANJIANRUO,ZHEIKENENGSHIYOUYUCMD1TUBIANZAOCHENGYIBUFENJIYINDEJIAJIHUASHUIPINGSHENGGAO,SHIDEBAOKUOYUSHIYINGQIANGGUANGYOUZHIJIEGUANXIDELHCSR3ZAINEIDEDUOGEJIYINDEBIAODASHOUDAOLEYIZHI,DAOZHIGUANGHEZUOYONGDEFUFANKUIDIAOJIEZUOYONGJIANRUO。ZHEIXIANGGONGZUOBUJINBAODAOLEYIZHONGQUANXINDEDNAXIUSHI5gmC,TONGSHIBAODAOLEYOUWEISHENGSUCJIEDAODEYIZHONGQUANXINDEMEIHUOFANYINGLEIXING,CHANSHULECMD1JIQICUIHUACHANWU5gmCZAIGUANGHEZUOYONGGUOCHENGZHONGDEZHONGYAODIAOKONGGONGNENG。ZHEIXIEYANJIUFENGFULEWOMENDUIDNAXIUSHIDUOYANGXINGDERENSHI。

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